Brainpaths Fingertip Tracing Devices Strengthen Synapse Connections: Repeated and Persistent Brain Stimulation IMPROVES MEMORY. Memory loss results when Amyloid plaque builds up in the brain and impairs synaptic neuron connections. Shankar GM, Li S, Lemere CA, et al. 2008. To improve memory, synapse connections must be strengthened. Brainpaths patented medical devices use repeated and persistent stimulation of the sensory cortex and Hippocampus of the brain, by repeatedly tracing injected plastic textures in Brainpaths devices, tracing with one or more fingertips, to increase and strengthen synapse connections. Brainpaths USPTO Utility patent (# 9,132,059) incorporates the Hebbian theory: neurons that fire together wire together. A synapse between two neurons is strengthened when the neurons on either side of the synapse (input and output) have highly correlated outputs. When activities wire repeatedly, the connections between those neurons strengthen, describing synaptic plasticity where an increase in synaptic efficacy arises from repeated and persistent stimulation of synapse connections between neurons. Repeated and Persistent Stimulation of the brain is what leads to the formation of memory. Eric Richard Kandel (born 11/7/29), an Austrian-American neuroscientist at Columbia University, is the recipient of the 2000 Nobel Prize for his research on the physiological basis of memory storage in neurons, including the Hebbian theory. Hebbian theory in neuroscience is an explanation for the adaptation of neurons in the brain during the learning process, describing a basic mechanism for synaptic plasticity: an increase in synaptic efficacy arises when the neurons on either side of the synapse (input and output) have highly correlated outputs.