CoAnn Technologies is established for developing/manufacturing high-resolution and high-sensitivity cutting-edge packed capillary nanoLC columns, including: Very small inner diameter (1530 um) ultra-sensitive columns for analysis of 1100 mammalian cells (cell size of ~10 um) and tiny tissues (smaller than 0.1 mm in size), High-resolution columns for protein/proteoform separation with peak capacities of 800-1,000, allowing top-down MS/MS identification of >1000 proteins and >5,000 proteofroms, High-resolution columns (peak capacities of >1,000) for peptide separation, allowing MS/MS identification of >50,000 peptides and >6,000 proteins, High-efficiency/sensitive columns for phosphorproteomics, allowing MS/MS identification of >20,000 phosphorpeptides for ~200 ng samples and >5,000 phosphorpeptides for ~10-ng samples, High-quality two-dimensional columns including analytical columns (MS/MS assignment of >20,000 peptides and >3,500 proteins for 10-ng samples) and fractionation columns (peak capacities of 500-1000), High-resolution columns (peak capacities of 500-1000) for separation of metabolites.