Sentinel Monitoring Systems, Inc. (Sentinel) is a venture-backed startup developing novel process monitoring systems for the life sciences industry. Sentinel was founded by a multidisciplinary team of experts, each with decades of experience in their respective fields and in the development and implementation of analytical systems. Sentinels initial product portfolio improves customers scientific understanding and effectiveness of their manufacturing processes through real-time monitoring of targeted materials online, at-line, and off-line. We are honored to include global leaders within the life sciences industry as our customers and collaborators. The Sentinel Online Monitor is a multivariate spectroscopic analyzer for real-time monitoring of bioburden and other target analytes. The Sentinel Sample Collector automatically collects excursion samples identified by online monitors and/or periodic samples during production runs. Other Sentinel products currently in development include automated online endotoxin monitoring and near real-time at-line systems for bioburden and specific organisms.