Separation Methods Technologies, Inc. (SMT) is a surface chemistry research and manufacturing corporation founded in 1993. SMT's goal is to provide chromatographers with outstanding HPLC specialty columns and bulk packing materials for various separation chemistries, ranging from analytical to process scale. The primary focus for SMT is on the creation of well-organized functional molecules on substrate surfaces for various functions, including chromatographic applications and materials engineering. SMT's novel, patented and proprietary, National Science Foundation awarded, Total Coverage technology utilizes advanced Self-Assembled Monolayers (SAM) to achieve bonded phase coverages that approach 100%. SMT's method of bonding allows the density of the functional ligands to be controlled with appropriate spacer molecules, a procedure that ensures highly cross-linked polysiloxane under layer structure. The results are bonded phases that are well protected and that show unprecedented resistance to both acid and base hydrolysis. Overall, SMT's HPLC columns and bulk resins are known to challenge many competitors in reusability, high and low pH tolerance and batch-to-batch reproducibility. Therefore, saving our clients time and money.